Substance SKN™

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    • Home
    • Shop
    • ABOUT US
      • Our Mission
      • Ingredient Philosophy
      • SHIPPING + RETURNS
      • Contact Us
      • Legal Statements
    • OUR SCIENCE
      • Results + Reviews
      • Substance SKN Science
      • Smarter Skin Longevity
      • Sustainability
    • OUR PRODUCTS
      • BIOADAPTIVE BALM
      • BIOACTIVE CLEANSING GEL
      • BIORENEWAL REPAIR
      • EYE MATRIX SERUM
      • EYE RECODE CREAM
      • CELLULAR RECOVERY CREAM
      • BIORECOVERY MASK
    • SKIN QUIZ
      • SUBSTANCE SKN QUIZ
      • Regimens With Substance

Substance SKN™

Substance SKN™ Substance SKN™ Substance SKN™
  • Home
  • Shop
  • ABOUT US
    • Our Mission
    • Ingredient Philosophy
    • SHIPPING + RETURNS
    • Contact Us
    • Legal Statements
  • OUR SCIENCE
    • Results + Reviews
    • Substance SKN Science
    • Smarter Skin Longevity
    • Sustainability
  • OUR PRODUCTS
    • BIOADAPTIVE BALM
    • BIOACTIVE CLEANSING GEL
    • BIORENEWAL REPAIR
    • EYE MATRIX SERUM
    • EYE RECODE CREAM
    • CELLULAR RECOVERY CREAM
    • BIORECOVERY MASK
  • SKIN QUIZ
    • SUBSTANCE SKN QUIZ
    • Regimens With Substance

Every Ingredient Has a Purpose. Every Formula Has Substance.

Every Ingredient Has a Purpose. Every Formula Has Substance.

Every Ingredient Has a Purpose. Every Formula Has Substance.

Every Ingredient Has a Purpose. Every Formula Has Substance.

Every Ingredient Has a Purpose. Every Formula Has Substance.

Every Ingredient Has a Purpose. Every Formula Has Substance.

BIORENEWAL SERUM Renew. Refine. Radiate.

There’s something captivating about skin that looks full of life. That luminous glow. That smooth, refined texture. The firmer-looking, beautifully supple complexion that makes you feel confident in your own skin. But late nights, environmental stress, dehydration, and the natural changes that come with time can leave your skin looking dull, tired, and less resilient than you’d like. Meet SUBSTANCE SKN™ BioRenewal Serum, a sophisticated, high-performance treatment designed to help improve the appearance of fine lines, uneven texture, firmness, and radiance—while supporting skin’s moisture barrier.


Thoughtfully formulated with peptides, antioxidants, and skin-conditioning actives, this lightweight serum goes beyond a fleeting burst of hydration to help skin look smoother, brighter, and more revitalized with consistent use. Its silky, fast-absorbing texture glides effortlessly onto skin, delivering a luxurious treatment experience without heaviness or residue. Wear it alone beneath moisturizer or make it the centerpiece of your daily skincare ritual. The beauty is in what comes next. A more luminous-looking complexion. Skin that feels hydrated and supple. A smoother, firmer-looking finish that reflects the care you give it every day. Because the future of your skin deserves more than a promise to look younger. It deserves a ritual worth looking forward to.


Your Skin’s Next Chapter Starts Here.

Skin appears brighter. Smoother. More resilient. More alive.

Unlike heavy creams that sit on the surface, Biorenewal Serum absorbs beautifully into the skin to provide lasting hydration without greasiness. 

The formula works to support the skin barrier while helping reduce the appearance of dullness, dryness, uneven tone, and rough texture — making it ideal for daily use across multiple skin types, including dehydrated, stressed, or environmentally compromised skin.

Every application helps reinforce what healthy skin needs most: hydration balance, barrier support, antioxidant defense, and visible radiance.

Daily Rituals Built With Substance

Why Your Skin Will Love It

  • Helps improve the appearance of fine lines and loss of firmness, leaving skin looking smoother, more supple, and beautifully revitalized.
  • Helps diminish the appearance of dullness and uneven texture for a brighter, more radiant-looking complexion.
  • A silky, fast-absorbing serum that delivers hydration and skin-conditioning care without heaviness or residue—layering effortlessly beneath your favorite moisturizer.

Application Instructions

PM: Apply SUBSTANCE SKN™ BioRenewal Serum in the evening to clean, dry skin before moisturizer. Dispense 1–2 pumps onto fingertips and gently press over the face, neck, and décolleté using upward motions. Allow to fully absorb before following with cellular recovery cream. 

Pro Tips

  • "Cocktail -your- glow"  by mixing one pump of BioRenewal Serum with your BioRecovery Mask or moisturizer in the palm of your hand for a customized skincare ritual and an extra boost of radiance.
  • Apply BioRenewal Serum to clean, dry skin before your moisturizer or BioRecovery Mask. Let it absorb, then seal in hydration for a beautifully smooth, supple-looking complexion.

Ingredient List

Water, Propanediol, Carnitine, Pentylene Glycol, Lactic Acid, Carnosine, Mandelic Acid, Trimethylglycine, Histidine, Sodium Hyaluronate, Salicylic Acid, Sodium Polyglutamate, Phenoxyethanol, Ethylhexylglycerin, Disodium EDTA.

Powered By Intelligent Skin Support

Biorenewal Serum Features

Multi-Acid Renewal Complex (Lactic Acid + Mandelic Acid + Salicylic Acid)- A combination of alpha and beta hydroxy acids selected to help exfoliate surface buildup, refine the appearance of uneven texture, and promote a smoother, more luminous-looking complexion.


Antioxidant & Skin-Conditioning Complex (Carnosine + Carnitine + Histidine)- A blend of skin-conditioning ingredients featuring carnosine, a peptide with antioxidant properties, to help care for skin exposed to everyday environmental stress and support a refreshed, healthy-looking appearance.


Multi-Dimensional Moisture Complex (Sodium Hyaluronate + Sodium Polyglutamate + Trimethylglycine (Betaine))-A moisture-attracting trio that helps hydrate and condition skin, leaving it feeling softer, smoother, and more supple while reducing the appearance of dehydration-related fine lines.

Frequently Asked Questions

Moisturizers can make skin look smoother. They temporarily plump the skin, which makes lines and wrinkles less visible. Moisturizers can be lotions, creams, gels and serums. They often contain water, oils and other ingredients, such as proteins, waxes, glycerin, lactate and urea.


Applying moisturizer before or with tretinoin does not make it significantly less effective, but it can reduce irritation and slow down absorption. This technique, often called "cocktailing" is a recommended strategy for minimizing dryness and peeling, especially for beginners


Application on dirty skin.  A good moisturizer helps to seal your skin barrier. The barrier keeps the moisture in and the outside world—full of bacteria, allergens, and irritants—out


The first product you should use in your daily routine is a non-drying, fragrance-free facial cleanser. The ideal face wash can cleanse and refresh your skin without over-stripping it or disrupting the skin's moisture barrier. The second skincare essential is a non-comedogenic face moisturizer.


Looking naturally beautiful every day is all about building simple habits that enhance your features and radiate health. The secret lies in a consistent routine of resetting your holistic balance by staying hydrated and replenishing your largest organ - skin, with daily usage of skincare built with Substance. 


Skincare serums are lightweight, highly concentrated liquids packed with active ingredients designed to penetrate deeper into the skin. Unlike traditional moisturizers that primarily hydrate the skin's surface, serums are meant to target specific complexion concerns such as aging, acne, or hyperpigmentation


Yes, you can use most face serums everyday, often twice daily (morning and night), to improve and maintain skin hydration, tone, and texture. Because serums contain high concentrations of active ingredients designed to penetrate deeply, daily use is generally encouraged to get the best, most consistent results


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